3D-FD72510 - dde-dapfmoc-oh | 1263046-98-5

Dde Biotin-PEG4-DBCO

Dde Biotin-PEG4-azide

Dde Biotin-PEG4-alkyne is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

Dde Biotin-PEG4-TAMRA-PEG4 Alkyne, a PEG-based PROTAC linker, facilitates PROTAC synthesis[1].

Dde Biotin-PEG4-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

Dde Biotin-PEG4-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

Dde Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker used for synthesizing PROTACs[1].

Azide-activated cleavable biotin probe

Dde biotin-PEG4-alkyne is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Dde biotin-PEG4-alkyne is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Dde biotin-PEG4-DBCO is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Dde biotin-PEG4-DBCO is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

The Nε-protecting group Dde is orthogonal to both Fmoc and Boc which allows on-resin modification of lysine side chains during Fmoc/tBu-based SPPS. The applications of Dde side-chain protection include synthesis of branched or di-epitopic peptides, preparation of MAP core molecules and lipo-MAPS, the synthesis of cyclic peptides, TASP molecules, and templates for combinatorial chemistry and synthetic proteins. Dde can be cleaved by 2% hydrazine in DMF.

The amino-protecting group Dde is orthogonal to both Fmoc and Boc protection and finds increasing application in the synthesis of modified peptides assembled by Fmoc-tBu solid-phase methodologies. Dde can be cleaved by 2 % hydrazine in DMF.

The Nδ-protecting group Dde is orthogonal to both Fmoc and Boc which allows on-resin modification of ornithine side chains during Fmoc/tBu-based SPPS. The applications of Dde side-chain protection include synthesis of branched or di-epitopic peptides, preparation of MAP core molecules and lipo-MAPS, the synthesis of cyclic peptides, TASP molecules, and templates for combinatorial chemistry and synthetic proteins. Dde can be cleaved by 2% hydrazine in DMF.