3D-FE131949 - ethyl-26-dimethyl-4-nitrophenoxyacetate

Applications 4-Nitrophenoxyacetic Acid is a butyl p-nitrophenyl ether metabolite. Plant growth regulatory activity.
References Yoshimura, H., et al.: Biochem. Pharmacol., 16, 1953 (1967); Aaberg, B.: Swedish J. Agric. Res., 10, 101 (1980)

4-Formyl-6-methoxy-3-nitrophenoxyacetic acid is a photolabile formylated nitrophenol that is used to study the formation of concentration gradients across cell membranes. 4-Formyl-6-methoxy-3-nitrophenoxyacetic acid has been found to react with proton gradients and formyl groups in the membrane, which produces formaldehyde. The reaction mechanism for this process is not well understood, but it has been proposed that the reaction proceeds through a transducing step in which an electron from the formyl group reacts with a proton gradient to produce a formate ion. This mechanism is supported by experiments that show that the rate of photochemical reactions increases as the pH gradient across the membrane decreases.

2-(4-Nitrophenoxy)acetohydrazide is a crystalline compound that can be used as a ligand for protein-ligand binding studies. It has also been shown to have anticancer activity in vitro against the human breast cancer cell line MCF-7. The bioassay results showed antiproliferative and proapoptotic effects on MCF-7 cells, and single crystal X-ray diffraction studies revealed that 2-(4-Nitrophenoxy)acetohydrazide is an inhibitor of the pyrazole derivatives x-ray structures, which are involved in cancer cell proliferation.