9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid

CAS : 69049-73-6

Ref. 3D-FE159137

Informations sur le produit

• Nom: 9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
• Synonymes: Nedocromil, 4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, 9-Ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, Fpl 59002, Fpl 59002Kp, Tilarin

Description

9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid (EDQ) is a nonsteroidal antiinflammatory agent that is used to treat asthma and other inflammatory diseases. It has been shown in the model system to inhibit the activity of polymorphonuclear leucocytes and cytosolic protein kinase C. EDQ has also been found to have an antiinflammatory effect by inhibiting eosinophil cationic protein release and neutrophil migration through inhibition of the production of cytokines such as IL1β and TNFα. The mechanism for this inhibition may be due to EDQ's ability to inhibit activation of nuclear factor kappa B.
EDQ is metabolized by cytochrome P450 enzymes and can cause drug interactions with other drugs that are metabol

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 371.34 g/mol
• Formule: C₁₉H₁₇NO₇
• Degré de pureté: Min. 95%
• InChI: InChI=1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26)
• Code InChI: InChIKey=RQTOOFIXOKYGAN-UHFFFAOYSA-N
• SMILES: CCCc1c2oc(C(=O)O)cc(=O)c2cc2c(=O)cc(C(=O)O)n(CC)c12