Fosfluconazole

CAS : 194798-83-9

Ref. 3D-FF34335

Informations sur le produit

• Nom: Fosfluconazole
• Synonymes: 2-(2,4-Difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propyl dihydrogen phosphate, 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-((1H-1,2,4-triazol-1-yl)methyl)ethyl dihydrogen phosphate, 1H-1,2,4-Triazole-1-ethanol, α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-, 1-(dihydrogen phosphate), 1H-1,2,4-Triazole-1-ethanol, α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-, dihydrogen phosphate (ester), 2,4-Difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol, dihydrogen phosphate (ester), 2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-yl dihydrogen phosphate, Procif, Prodif, Uk-292,663, Unii-3Jij299Ewh
• CAS: 194798-83-9

Description

Fosfluconazole is an antifungal drug that belongs to the group of polyunsaturated compounds. It is used for the treatment of fungal infections, such as cryptococcal meningitis, esophageal candidiasis, and onychomycosis. Fosfluconazole is a prodrug that is converted in vivo to fluconazole. This conversion takes place through hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Fosfluconazole has been shown to be effective against a variety of fungi, including Candida species and Cryptococcus neoformans. Fosfluconazole binds to ergosterol in the fungal cell membrane and inhibits the synthesis of ergosterol peroxide (a major component of fungal cell membranes), leading to increased permeability of the

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 386.25 g/mol
• Formule: C₁₃H₁₃F₂N₆O₄P
• Degré de pureté: Min. 95%
• InChI: InChI=1S/C13H13F2N6O4P/c14-10-1-2-11(12(15)3-10)13(25-26(22,23)24,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9H,4-5H2,(H2,22,23,24)
• Code InChI: InChIKey=GHJWNRRCRIGGIO-UHFFFAOYSA-N
• SMILES: O=P(O)(O)OC(Cn1cncn1)(Cn1cncn1)c1ccc(F)cc1F