Daun02

CAS : 290304-24-4

Ref. 3D-FG64997

Informations sur le produit

• Nom: Daun02
• Synonymes: N-[4-(b-d-Galactopyranosyl)-3-nitrobenzyloxycarbonyl]daunomycin[3-nitro-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan- 2-yl]oxyphenyl]methyl N-[(2S,3S,4S,6R)-6-[(3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl)

Description

A prodrug of the DNA-intercalating agent daunorubicin with anti-tumoral activity, used for suicide gene therapy and activity-dependent ablation of cells. Daun02 is an inactive form of the toxin, which gets activated upon cleavage with prodrug-activating enzyme β-galactosidase, yielding daunorubicin. Genetic constructs have been designed carrying the lacZ gene, coding for β-galactosidase, under control of application-specific promoters. The cells expressing the β-gal undergo cell death since the enzyme hydrolizes the prodrug into the active toxin.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 884.24874
• Formule: C₄₁H₄₄N₂O₂₀
• Degré de pureté: Min. 95%
• Couleur/Forme: Red To Brown Solid