2-Hydroxy atorvastatin lactone

CAS : 163217-74-1

Ref. 3D-FH23908

Informations sur le produit

• Nom: 2-Hydroxy atorvastatin lactone
• Synonymes: 5-(4-Fluorophenyl)-N-(2-hydroxyphenyl)-2-(1-methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-p yrrole-3-carboxamide

Description

2-Hydroxyatorvastatin lactone is a prodrug of atorvastatin, which is an HMG-CoA reductase inhibitor. It is used to lower cholesterol and triglycerides in the blood. The drug is administered as a tablet, capsule, or liquid and can be taken with or without food. 2-Hydroxyatorvastatin lactone is metabolized by cytochrome P450 enzymes in the liver to produce active atorvastatin. This metabolism may be inhibited by other drugs that are also metabolized by cytochrome P450 enzymes, such as erythromycin and ketoconazole. 2-Hydroxyatorvastatin lactone has been shown to have an inhibition constant (Ki) of 0.5 μM for human liver microsomes and plasma concentrations of 1 μM or higher are required for therapeutic effect.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 556.62 g/mol
• Formule: C₃₃H₃₃FN₂O₅
• Degré de pureté: Min. 95%
• Couleur/Forme: Off-White Slightly Yellow Powder
• InChI: InChI=1S/C33H33FN2O5/c1-20(2)31-30(33(40)35-26-10-6-7-11-27(26)38)29(21-8-4-3-5-9-21)32(22-12-14-23(34)15-13-22)36(31)17-16-25-18-24(37)19-28(39)41-25/h3-15,20,24-25,37-38H,16-19H2,1-2H3,(H,35,40)/t24-,25-/m1/s1
• Code InChI: InChIKey=MNECBMZJZFGTIK-JWQCQUIFSA-N
• SMILES: CC(C)c1c(C(=O)Nc2ccccc2O)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H]1C[C@@H](O)CC(=O)O1