8-Hydroxy mianserin

CAS : 57257-81-5

Ref. 3D-FH24049

Informations sur le produit

• Nom: 8-Hydroxy mianserin
• Synonymes: 1,2,3,4,10,14b-Hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepin-8-ol8-Hydroxymianserin, 2H-Dibenzo(c,f)pyrazino(1,2-a)azepin-8-ol, 1,2,3,4,10,14b-hexahydro-2-methyl-

Description

8-Hydroxy mianserin is an active metabolite of the antidepressant drug mianserin. It has been shown to have significant cytotoxicity against human liver cells and potent antagonists of the 5-HT2A receptor. The 8-hydroxy metabolite is formed by oxidative deamination catalyzed by cytochrome P450, followed by hydrolysis. The stereoselectivity of the reaction is due to the fact that only the levorotatory enantiomer is reactive with the enzyme. 8-Hydroxy mianserin binds to the receptor in a way that prevents agonist binding, thus acting as an antagonist. It has also been shown to inhibit uptake of carbamazepine, which may account for its anti-epileptic effects.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 280.36 g/mol
• Formule: C₁₈H₂₀N₂O
• Degré de pureté: Min. 95%
• InChI: InChI=1S/C18H20N2O/c1-19-8-9-20-17-7-6-15(21)11-14(17)10-13-4-2-3-5-16(13)18(20)12-19/h2-7,11,18,21H,8-10,12H2,1H3
• Code InChI: InChIKey=YTMQIPGEXLWJTN-UHFFFAOYSA-N
• SMILES: CN1CCN2c3ccc(O)cc3Cc3ccccc3C2C1