4-Hydroxy midazolam
CAS : 59468-85-8
Ref. 3D-FH24051
1mg | 482,00 € | ||
2mg | 514,00 € | ||
5mg | 686,00 € | ||
10mg | 980,00 € | ||
25mg | 1.844,00 € |
Informations sur le produit
- 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol
- 4H-Imidazo(1,5-a)(1,4)benzodiazepin-4-ol, 8-chloro-6-(2-fluorophenyl)-1-methyl-
Midazolam is a benzodiazepine that is used for the treatment of anxiety, insomnia, and epilepsy. It is a p-gp substrate and is transported by this transporter protein from the inside to the outside of cells. 4-Hydroxy midazolam (4OHM) is an active metabolite of midazolam that has dna binding activity. The drug exhibits matrix effects on human pharmacokinetics and metabolism. 4OHM binds to DNA in a sequence-specific manner, which inhibits transcription and replication. This compound also inhibits hepatic enzymes such as CYP3A4, CYP2B6, CYP2C9, and CYP2C19. The analytical method used to detect 4OHM in blood samples is HPLC with UV detection at 254 nm. This active form has been shown to be biotransformed into 1'-hydroxy midazolam (1'OHM).
Propriétés chimiques
Question d’ordre technique sur : 3D-FH24051 4-Hydroxy midazolam
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