3''-Hydroxy simvastatin

Ref. 3D-FH24126

Informations sur le produit

• Nom: 3''-Hydroxy simvastatin
• Synonymes: 3-Hydroxy-2,2-dimethylbutanoic acid 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naph thalenyl ester
• Marque: Biosynth
• Description: 3''-Hydroxy simvastatin is a potent and selective inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonate in the cholesterol biosynthetic pathway. It inhibits the production of cholesterol and other steroids, including glucocorticoids, mineralocorticoids, and sex hormones. 3''-Hydroxy simvastatin is used to lower blood cholesterol levels in patients with hypercholesterolemia. The acid form of 3''-hydroxy simvastatin is detectable by fluorescent probes in biological fluids at concentrations as low as 1 nanomolar. The lactone form of 3''-hydroxy simvastatin has been shown to have similar potency as atorvastatin.

Propriétés chimiques

• Masse moléculaire: 434.57 g/mol
• Formule: C₂₅H₃₈O₆
• Degré de pureté: Min. 95%
• Couleur/Forme: White Slightly Yellow Powder