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3-(3-Iodophenyl)acrylic acid is a molecule with diagnostic and research purposes. It can be labeled with a radiolabel and used as a diagnostic probe for the striatum. 3-(3-Iodophenyl)acrylic acid binds to receptors in the striatum, which are important in the regulation of motor function. The affinity of this molecule is due to its similarity to adenosine, which is an endogenous neurotransmitter that binds to these receptors. 3-(3-Iodophenyl)acrylic acid has been shown to be useful for quantifying angiotensin II in plasma samples using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. This molecule also has high affinity for various analytes from the nervous system, such as acetylcholine and serotonin, which have been detected using MALDI analysis.