Isoastragaloside I

CAS : 84676-88-0

Ref. 3D-FI74369

Informations sur le produit

• Nom: Isoastragaloside I
• Synonymes: astragalosideⅠ, (3beta,6alpha,16beta,20R,24S)-3-[(2,4-Di-O-acetyl-beta-D-xylopyranosyl)oxy]-20,24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl beta-D-glucopyranoside

Description

Isoastragaloside I is a natural compound that is extracted from the Chinese herb, Isatis indigotica. It has shown to have anti-inflammatory activity in vitro and in vivo, and may be a potential therapeutic agent for inflammatory bowel disease. Isoastragaloside I inhibits the activation of toll-like receptor 4 (TLR4) which can stimulate inflammation. This inhibition may be due to its ability to suppress TLR4-mediated activation of nuclear factor kappa B (NFκB) and subsequent production of proinflammatory cytokines such as tumor necrosis factor α (TNFα). The cytotoxicity of isoaistragaloside I was evaluated using bovine fetal liver cells. It showed no toxicity on cells at concentrations up to 1000 μM, demonstrating that it is safe for use in vivo.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 869.04 g/mol
• Formule: C₄₅H₇₂O₁₆
• Degré de pureté: Min. 95%