2-(Isopropylsulphonyl)aniline
CAS : 76697-50-2
Ref. 3D-FI75046
| 1g | Arrêté | ||
| 2g | Arrêté | ||
| 5g | Arrêté | ||
| 10g | Arrêté | ||
| 25g | Arrêté |
Informations sur le produit
Nom :
2-(Isopropylsulphonyl)aniline
Synonymes :
- 1-Amino-2-(isopropylsulfonyl)benzene
- 2-Isopropylsulfonylaniline
- 1-Amino-2-(isopropylsulphonyl) benzene
- 2-(Isopropylsulfonyl)Aniline
- 2-(Propane-2-Sulfonyl)-Phenylamine
- 2-(Isopropylsulfonyl)Benzenamine
Description :
2-(Isopropylsulphonyl)aniline (2-ISA) is a potent and selective inhibitor of the mitotic checkpoint kinase Mad2, which is implicated in cancer. 2-ISA has been shown to inhibit the mitotic spindle assembly checkpoint by binding to Mad2 and inhibiting its ability to phosphorylate Mad1 and Cdc20. In vitro experiments have demonstrated that 2-ISA blocks cell cycle progression in ht-29 cells, a colon cancer cell line, by preventing their entry into mitosis. 2-ISA has been shown to be an effective inhibitor of tumor growth in vivo. This agent also inhibits sorafenib, a drug that targets the Raf/MEK/ERK signaling pathway and is used for the treatment of cancer. The analogs of 2-ISA are being developed as potential anticancer agents.
Avis:
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Marque:
Biosynth
Stockage à long terme :
Notes :
Propriétés chimiques
Masse moléculaire :
199.27 g/mol
Formule :
C9H13NO2S
Degré de pureté :
Min. 95%
InChI :
InChI=1S/C9H13NO2S/c1-7(2)13(11,12)9-6-4-3-5-8(9)10/h3-7H,10H2,1-2H3
Code InChI :
InChIKey=GMLAMRMKROYXNZ-UHFFFAOYSA-N
SMILES :
CC(C)S(=O)(=O)c1ccccc1N
MDL:
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