1-Methyluric acid

CAS : 708-79-2

Ref. 3D-FM08042

Informations sur le produit

• Nom: 1-Methyluric acid
• Synonymes: 1-Methyl-2,6,8-trihydroxypurine, 1-Methyl-1H-purine-2,6,8(3H,7H,9H)-trione, 1-Methyl-2,3,6,7,8,9-hexahydro-1H-purine-2,6,8-trione, 1-Methyl-7,9-dihydro-3H-purine-2,6,8-trione, 1-methyl-7,9-dihydro-1H-purine-2,6,8(3H)-trione, 1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-1-methyl-, 7,9-Dihydro-1-methyl-1H-purine-2,6,8(3H)-trione, N¹-Methyluric acid, Uric acid, 1-methyl-, N1-Methyluric acid

Description

1-Methyluric acid is a purine derivative that is a metabolite of caffeine. It is formed by the hepatic cytochrome P450 enzyme system and excreted in the urine. 1-Methyluric acid has been shown to be metabolized by rat liver microsomal enzymes, with the production of malonic acid, which may be responsible for its observed hepatotoxicity. The drug has also been shown to have an antibody response in rats and has been found to inhibit the activity of human liver enzymes. It also inhibits rat kidney enzyme activities and causes renal toxicity in rats. There are many drug interactions that can occur with 1-methyluric acid, including those with warfarin, phenytoin, carbamazepine, and diazepam. This drug should not be used in patients with severe renal impairment or chronic renal failure because it can cause acute renal failure due to its high degree of protein binding and rapid elimination from the body.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 182.14 g/mol
• Formule: C₆H₆N₄O₃
• Degré de pureté: Min. 98 Area-%
• Couleur/Forme: White Powder
• InChI: InChI=1S/C6H6N4O3/c1-10-4(11)2-3(9-6(10)13)8-5(12)7-2/h1H3,(H,9,13)(H2,7,8,12)
• Code InChI: InChIKey=QFDRTQONISXGJA-UHFFFAOYSA-N
• SMILES: Cn1c(=O)[nH]c2[nH]c(=O)[nH]c2c1=O