Informations sur le produit
- 1-Methyl-4-piperidinemethanol
- N-Methyl-4-piperidinemethanol
- (1-Methylpiperidin-4-Yl)Methanol
- 4-(Hydroxymethyl)-1-methylpiperidine
(1-Methylpiperidin-4-yl)methanol is a potent inhibitor of the kinases vegfr-2 and vesicular glutamate transporter 2 (vglut2). It is also active against human tumor xenografts. The inhibitory activity was determined to be due to its ability to bind and covalently modify tyrosine residues in the kinase domain. The inhibitory potency of (1-Methylpiperidin-4-yl)methanol was found to be constant, regardless of oxygenation status. This suggests that the inhibition is not due to the binding of oxygenated metabolites. In vitro experiments showed that it inhibits cellular proliferation by blocking protein synthesis and arresting cells at G1 phase. This drug has potential as an antitumor agent because it inhibits tumor growth without affecting normal tissue or causing significant toxicity in animal models.
Propriétés chimiques
Question d’ordre technique sur : 3D-FM12073 (1-Methylpiperidin-4-yl)methanol
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