Informations sur le produit
- (8b)-9,10-Didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-ergoline-8-carbox-amide maleateN-[a-(Hydroxymethyl)propyl]-D-lyse
- (8beta)-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-9,10-didehydroergoline-8-carboxamide (2Z)-but-2-enedioate (salt)
- Basofortina
- Erezin
- Ergoline-8-carboxamide, 9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-, (8β)-, (2Z)-2-butenedioate (1:1) (salt)
- Ergonovine, methyl-, compd. with maleic acid
- Indolo[4,3-fg]quinoline, ergoline-8-carboxamide deriv.
- Metenarin
- Methergin
- Methergine
- Voir d'autres synonymes
- Methyl ergometrine maleate
- Methylergobasine maleate
- Methylergometrine Maleate
- Ryegonovin
- Spametrin F
- Methylergonovine maleate
Methylergonovine maleate salt is a prodrug of methylergometrine. It is a potent vasoconstrictor that has been used to treat severe hypertension, although it has been largely replaced by other drugs such as hydralazine and minoxidil. Methylergonovine maleate salt is also used to prevent and treat pulmonary edema in heart failure patients. This drug binds to the alpha-adrenergic receptor on vascular smooth muscle cells, leading to an increase in intracellular calcium ion concentration and vasoconstriction. The pharmacokinetics of methylergonovine maleate salt have been studied in healthy subjects using a pharmacokinetics study with LC-MS/MS method. Results show that this drug has low potency, with an elimination half-life of about 2 hours. Methylergonovine maleate salt is metabolized by esterases or glucuronidases, oxidized by cytochrome P
Propriétés chimiques
Question d’ordre technique sur : 3D-FM25836 Methylergonovine maleate salt
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