2-(4-Nitrophenyl)imidazo[1,2-a]pyridine

CAS : 3323-26-0

Ref. 3D-FN131943

Informations sur le produit

• Nom: 2-(4-Nitrophenyl)imidazo[1,2-a]pyridine
• Synonymes: imidazo[1,2-a]pyridine, 2-(4-nitrophenyl)-, 2-(4-Nitro-phenyl)-imidazo[1,2-a]pyridine, Imidazo[1,2-a]pyridine, 2-(4-nitrophenyl)-, Imidazo[1,2-a]pyridine, 2-(p-nitrophenyl)-

Description

2-(4-Nitrophenyl)imidazo[1,2-a]pyridine (NPI) is an orally active fluorescent probe for angiotensin II receptor type 1 (AT1). The fluorescence of NPI is quenched in the presence of AT1. Under conditions with high concentrations of AT1, the fluorescence of NPI changes from green to red. This property allows the measurement of AT1 levels in cells and tissues. In addition, NPI is a substrate for phenacyl choline esterase that catalyzes the hydrolysis of 2-(4-nitrophenyl)-imidazo[1,2-a]pyridine to 2-(4-nitrophenyl)-3-hydroxypyridine. The reaction time and temperature are dependent on the substrate concentration as well as pH and ionic strength. Reaction times increase with decreasing pH and increasing ionic strength.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 239.23 g/mol
• Formule: C₁₃H₉N₃O₂
• Degré de pureté: Min. 95%