Informations sur le produit
- Mono-methyl 5-nitroisophthalate
5-Nitroisophthalic acid monomethyl ester (NIAE) is an acetylating agent that can be used for the preparation of 5-nitroisophthalic acid, which is a precursor to the synthesis of dyes and pharmaceuticals. The acetylation reaction of NIAE with proteins produces an insensitive material. Acetylation also inhibits the activity of serine proteases and virus replication. In addition, it has been found that the catalytic reduction of NIAE with palladium is faster than other synthetic methods. Optimal reaction conditions are obtained by adding chloride ions to the reaction mixture, while reductive conditions are optimal for catalysis. Reaction time can be shortened by using a soluble catalyst such as iodide ion or mercury(II) sulfate. The active site of NIAE contains a nitro group that reacts with substrates in the presence of oxygen, forming a product from which the acetyl group has been removed
Propriétés chimiques
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