Informations sur le produit
Nom :
Salubrinal
Synonymes :
- (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
- (2E)-3-Phenyl-N-{2,2,2-trichloro-1-[(quinolin-8-ylcarbamothioyl)amino]ethyl}acrylamide
- 2-propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-, (2E)-
Description :
Salubrinal is a protein synthesis inhibitor that binds to the eukaryotic initiation factor 2-alpha (eIF2α) and prevents its phosphorylation, which leads to inhibition of mRNA translation and protein synthesis. Salubrinal is used for the treatment of bowel diseases, including ulcerative colitis. It has been shown to induce apoptosis in HL-60 cells, as well as axonal growth in mice with spinal cord injury. This drug also blocks the apoptosis pathway by inhibiting caspase activation and blocking mitochondrial membrane permeability. Salubrinal is highly selective for eIF2α but not other serine/threonine kinases such as PKR or IKK.
Avis:
Nos produits sont destinés uniquement à un usage en laboratoire. Pour tout autre usage, veuillez nous contacter.
Marque:
Biosynth
Stockage à long terme :
Notes :
Propriétés chimiques
Masse moléculaire :
479.81 g/mol
Formule :
C21H17N4OSCl3
Degré de pureté :
Min. 95%
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