6-Trifluoromethyloxindole

CAS : 1735-89-3

Ref. 3D-FT36785

Informations sur le produit

• Nom: 6-Trifluoromethyloxindole
• Synonymes: 6-Trifluoromethvl-2-Oxindole, 6-Trifluoromethyl-2-Oxindole, 6-(Trifluoromethyl)-1,3-Dihydro-2H-Indol-2-One, Buttpark 24\07-32, 6-(Trifluoromethyl)-2-Oxoindole, 6-(Trifluoromethyl)Oxindole

Description

6-Trifluoromethyloxindole is an antimalarial drug that belongs to the quinolines class of drugs. It has shown antimalarial activity against plasmodium falciparum, the most deadly form of malaria. 6-Trifluoromethyloxindole is synthesized in a similar manner to quinazolines, but with a 4-aminophenol group instead of an N-(pyridin-2-yl) group. The synthesis starts with the reaction of 1,4-benzenediamine and 2,6-dichloroquinoline in the presence of ammonium chloride to give 2-(6-chloroquinolin)-1,4-benzenediamine. The amine is then reacted with trifluoromethyl iodide and potassium carbonate to form 6-(trifluoromethyl)oxindole.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 201.15 g/mol
• Formule: C₉H₆F₃NO
• Degré de pureté: Min. 95%
• InChI: InChI=1S/C9H6F3NO/c10-9(11,12)6-2-1-5-3-8(14)13-7(5)4-6/h1-2,4H,3H2,(H,13,14)
• Code InChI: InChIKey=LZPKWQOLOCLSBO-UHFFFAOYSA-N
• SMILES: O=C1Cc2ccc(C(F)(F)F)cc2N1