Informations sur le produit
INI-43 is a small molecule that is a potent inducer of apoptosis. It binds to the TNF-related apoptosis-inducing protein (TNFAIP) and induces apoptosis in cancer cells by activating caspases. INI-43 also inhibits the nuclear translocation of NF-κB, which is a transcription factor that regulates proinflammatory cytokines. This inhibition prevents inflammation and tumor growth. The binding of INI-43 to TNFAIP leads to a conformational change in TNFAIP that activates caspases, resulting in apoptosis. In vitro assays have shown that INI-43 has an IC50 value of 0.1 nM for cervical cancer cells and 1 nM for mammary adenocarcinoma cells. The binding affinity of INI-43 to TNFAIP is greater than its affinity for other proteins, such as p65 or IKKβ, which may explain the selectivity of this drug towards tumor cells
Propriétés chimiques
Question d’ordre technique sur : 3D-GKB04601 INI-43
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