3D-IDA48533 - 2-methoxy-5-methylthiophenol | 83485-33-0

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

5-Tert-Butyl-2-Methylthiophenol

4-Methylthiophenol

3-Chloro-2-methylthiophenol

2-Fluoro-3-methylthiophenol

3-Fluoro-4-methylthiophenol

5-Chloro-2-methylthiophenol

3-Methylthiophenol

4-Hydroxy-3-methylthiophenol

2-Methylthiophenol

4-Fluoro-3-methylthiophenol

4-Fluoro-2-methylthiophenol

4-Methylthiophenol is a colorless liquid that is soluble in water. It has a molecular weight of 98.12 and an empirical formula of C6H7O2S. 4-Methylthiophenol is used as an analytical reagent, solvent, and chemical intermediate. It exhibits hydrogen bonding interactions with sodium carbonate and trifluoroacetic acid and forms a salt with sodium carbonate. The molecule's stability increases when it interacts with amines and the presence of nucleophiles such as water or alcohols. 4-Methylthiophenol has been shown to be effective at enhancing the fluorescence signal emitted by amines, which makes it useful for laser ablation mass spectrometry (LA-MS). 4-Methylthiophenol can also be used for kinetic energy measurements using FTIR spectroscopy because it will absorb infrared light at 1680 cm−1 from the CO2 laser beam.

5-tert-Butyl-2-methylthiophenol (5BMS) is a skin irritant that is used in regenerative medicine as an alternative to animal testing. 5BMS has been shown to be a potent inhibitor of COX1 and COX2, and it inhibits the synthesis of prostaglandin E2 by inhibiting the activity of the enzyme cyclooxygenase (COX). 5BMS has also been shown to inhibit other enzymes involved in inflammatory responses, such as lipoxygenase, leukotriene C4 synthase, and thromboxane A2 synthase. The use of 5BMS for skin irritation studies has been validated in vivo using a skin model with histology and regulatory tissues including human skin tissue. This test is done on isolated human tissues or cells under conditions that replicate potential exposure conditions.