Camostat Mesilate

CAS : 59721-29-8

Ref. 3D-ISP-3606-PI

Informations sur le produit

• Nom: Camostat Mesilate
• Synonymes: 2-(Dimethylamino)-2-oxoethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulphonate, Benzeneacetic acid, 4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-, 2-(dimethylamino)-2-oxoethyl ester, methanesulfonate (1:1), Benzeneacetic acid, 4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-, 2-(dimethylamino)-2-oxoethyl ester, monomethanesulfonate, Camostat mesylate, Camostat monomethanesulfonate, Foipan, Foy 305, Foy-S 980, N-(diaminomethylidene)-4-[(4-{2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl}phenoxy)carbonyl]anilinium methanesulfonate

Description

Camostat mesilate is a prodrug that is metabolized to the active form, pemastatin. It is used for the treatment of bowel disease and squamous cell carcinoma. Camostat mesilate inhibits the TNF-α receptor by binding to its response element in vitro and in vivo. The biological properties of camostat mesilate are due to its ability to inhibit TNF-α production by binding to the TNF-α receptor, thereby preventing activation of transcription factors such as nuclear factor kappa B (NFκB). In vitro assays have shown that camostat mesilate induces apoptosis in human carcinoma cell lines through inhibition of growth factor-β1. This drug has also been shown to be effective in treating viral infections, including HIV and herpes zoster.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 494.5 g/mol
• Formule: C₂₀H₂₂N₄O₅•CH₃SO₃H
• Degré de pureté: Min. 95%