BMS-833923

CAS : 1059734-66-5

Ref. 3D-JSB73466

Informations sur le produit

• Nom: BMS-833923
• CAS: 1059734-66-5

Description

BMS-833923 is a small molecule that inhibits the activity of epidermal growth factor receptor (EGFR) tyrosine kinase in hypoxic tumor cells, which are found in approximately one-third of all solid tumors. BMS-833923 has been shown to inhibit EGFR tyrosine kinase activity by binding to the ATP site of EGFR and blocking the formation of ATP-EGFR complexes. The inhibition leads to a decrease in downstream signaling, including decreased activation of the mitogen-activated protein kinases and p38 MAPK pathways. BMS-833923 has also been shown to be active against metastatic pancreatic cancer cells. Pharmacokinetic studies have shown that BMS-833923 is metabolized via CYP3A4/5; however, this does not affect its antitumor activity or toxicity.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 473.58 g/mol
• Formule: C₃₀H₂₇N₅O
• Degré de pureté: Min. 95%