Leptomycin A

CAS : 87081-36-5

Ref. 3D-MDA08136

Informations sur le produit

• Nom: Leptomycin A
• Marque: Biosynth
• Description: Leptomycin A is a Streptomyces-produced inhibitor, which is derived from the bacterium Streptomyces spiroverticillatus. It functions by specifically binding to and inhibiting the CRM1 (exportin 1), a nuclear export receptor. This action blocks the nuclear export of proteins that contain a leucine-rich nuclear export signal (NES), thereby leading to their accumulation within the nucleus. The inhibition of CRM1 disrupts various cellular processes, including cell cycle regulation and signal transduction pathways.

Propriétés chimiques

• Masse moléculaire: 526.7 g/mol
• Formule: C₃₂H₄₆O₆
• Degré de pureté: Min. 95%