1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucose

CAS : 188783-78-0

Ref. 3D-MT15919

Informations sur le produit

• Nom: 1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucose
• Synonymes: Peracetylated 2-fluoro 2-deoxy-L-fucose

Description

Peracetylated 2-fluoro-L-fucose is the acetylated form of 2-deoxy-2-fluoro-L-fucose which is a potent inhibitor of protein fucosylation. It exhibits improved cell permeability and is rapidly deacetylated into its active form, inside the cell. It is metabolised inside the cell into a corresponding donor substrate analogue of GDP-fucose or GDP-2FF, via the salvage pathway. GDP-2FF accumulates in the cell causing a shutdown of de novo pathway which leads to the desired fucosylation inhibition. The addition of 100 uM peracetylated-2-fluoro-L-fucose to plants severely inhibits root growth by 95% compared to an untreated plant, and is more potent compared to 2-fluoro-L-fucose. The material is soluble in DMSO at 10mg/ml.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 292.26 g/mol
• Formule: C₁₂H₁₇FO₇
• Degré de pureté: Min. 97 Area-%
• Couleur/Forme: White Off-White Powder