Informations sur le produit
- Triantennary GalNAc-NH2 TFA Salt (peracetate)Tri-GalNAc-NH2 TFA Salt (peracetate)Trivalent GalNAc-NH2 TFA Salt (peracetate)Tris-G alNAc-NH2 TFA Salt (peracetate)Tris-β-GalNAc-amine TFA saltTrimeric GalNAc-NH2 TFA Salt (peracetate)Tris β-D-N-acetylgal
Tri-b-GalNAc-amine TFA salt is an ASGPR-targeted ligand for therapeutics and diagnostics. With three terminal beta-GalNAc (N-acetylgalactosamine) sugars in a trivalent configuration, its high-affinity permits binding to the asialoglycoprotein receptor (ASGPR) on hepatocytes. Notably, the presence of a protonated primary amine group allows for chemoselective bioconjugation with various functional moieties via established amide bond formation techniques. Its salt form (TFA salt) enhances the water solubility of the molecule, facilitating its use in aqueous reaction buffers commonly employed in bioconjugation protocols. This combination of specific ASGPR targeting and a readily available conjugation site makes tri-b-GalNAc-amine TFA a valuable tool for the development of customized and targeted drug-GalNAc conjugates, siRNA delivery vehicles, or ASGPR-specific probes. The use of TFA as a counterion ensures efficient deprotonation of the amine during conjugation, potentially improving reaction efficiency.
Propriétés chimiques
Question d’ordre technique sur : 3D-MT184247 Tri-b-GalNAc-amine TFA salt
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