8-(2-Aminoethyl)aminoadenosine 3',5'-cyclic monophosphate

CAS : 61363-29-9

Ref. 3D-NA09017

Informations sur le produit

• Nom: 8-(2-Aminoethyl)aminoadenosine 3',5'-cyclic monophosphate
• Synonymes: 8-AEA-cAMP8-(2-Aminoethyl)amino-D-adenosine-3',5'-cyclic monophosphate
• Marque: Biosynth
• Description: 8-(2-Aminoethyl)aminoadenosine 3',5'-cyclic monophosphate (8-AEACMP) is a structural analog of the purine nucleotide adenosine. It has been shown to be an effective inhibitor of HIV replication in vitro and in vivo. 8-AEACMP blocks HIV transcription by binding to the cellular target, the enzyme ribonucleotide reductase. This binding prevents the formation of an enzyme-substrate complex that is required for DNA synthesis. 8-AEACMP binds to two sites on this enzyme: one site is at a catalytic site that is not involved in substrate binding, and the other site is at a regulatory site. The inhibitory effect of 8-AEACMP on HIV transcription results from its ability to bind at both sites simultaneously.

Propriétés chimiques

• Masse moléculaire: 387.29 g/mol
• Formule: C₁₂H₁₈N₇O₆P
• Degré de pureté: Min. 95%