5'-Amino-5'-deoxyguanosine

CAS : 4099-84-7

Ref. 3D-NA16031

Informations sur le produit

• Nom: 5'-Amino-5'-deoxyguanosine
• Synonymes: 2H-purin-6-ol, 9-(5-amino-5-deoxypentofuranosyl)-3,9-dihydro-2-imino-

Description

5'-Amino-5'-deoxyguanosine (5-ADG) is an intermediate in the de novo synthesis of guanine nucleotides. It can be synthesized from 5-aminoimidazole ribonucleotide and guanosine monophosphate (GMP). 5-ADG is a substrate for the enzyme GTP cyclohydrolase, which converts it to GMP. This intermediate can also be formed by the action of phosphoryl chloride on 5-aminoimidazole ribonucleotide. The reaction of 5-ADG with malonic acid leads to the formation of inosinic acid, which has been postulated to be a precursor of purines. This conversion is catalyzed by adenylosuccinate synthetase and the enzyme adenylosuccinase.

The reaction mechanism for this reaction includes two steps: a substitution step and a ligation step. In

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 282.26 g/mol
• Formule: C₁₀H₁₄N₆O₄
• Degré de pureté: Min. 95 Area-%
• Couleur/Forme: Powder