5-Bromo-2'-deoxycytidine

CAS : 1022-79-3

Ref. 3D-NB06450

Informations sur le produit

• Nom: 5-Bromo-2'-deoxycytidine
• Synonymes: 5-Bromo-2'-deoxy-D-cytidine, 4-amino-5-bromo-1-(2-deoxypentofuranosyl)pyrimidin-2(1H)-one, 4-amino-5-bromo-1-[(3xi)-2-deoxy-beta-D-glycero-pentofuranosyl]pyrimidin-2(1H)-one, 5-Bromodeoxycytidine, Bcdr, Brcdr, Brn 0027385, Bromodeoxycytidine, C.A.S. 1,022,793, Cytidine, 5-bromo-2'-deoxy-, Nsc 61765

Description

5-Bromo-2'-deoxycytidine is a synthetic nucleoside analogue that is used to treat diabetic neuropathy. It is structurally similar to cytidine, and inhibits the enzyme DNA polymerase by intramolecular catalysis. This causes deamination of the 5-bromo group, which prevents further synthesis of DNA. 5-Bromo-2'-deoxycytidine has been shown to be effective in vivo in a mouse model for inflammatory bowel diseases, including colitis and eosinophilic enteritis. The drug was also found to inhibit the production of Eosinophil peroxidase from HL-60 cells in vitro.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 306.11 g/mol
• Formule: C₉H₁₂BrN₃O₄
• Degré de pureté: Min. 95%
• Couleur/Forme: Off-White Powder