4-(N-Butyl-N-nitrosamino)butyric Acid

CAS : 38252-74-3

Ref. 3D-NBA25274

Informations sur le produit

• Nom: 4-(N-Butyl-N-nitrosamino)butyric Acid
• Synonymes: 4-(Butylnitrosoamino)butanoic acid, Butanoic Acid, 4-(Butylnitrosoamino)-, Butyl(3-carboxypropyl)nitrosamine, N-Butyl-N-(3-carboxypropyl)nitrosamine, 4-[Butyl(nitroso)amino]butanoic acid

Description

4-(N-Butyl-N-nitrosamino)butyric Acid (4-NBB) is a potent carcinogen that has been shown to induce bladder cancer in animals following administration by intravesical instillation. 4-NBB is a metabolite of the tobacco-specific nitrosamine, N′-nitrosonornicotine (NNN). The carcinogenic activity of 4-NBB was demonstrated in a number of in vitro and in vivo studies. In vitro assays with human bladder cells showed that 4-NBB induced DNA damage and mutation frequency. Wild type mice treated with 4-NBB developed cancers at the site of injection, whereas wild type mice not exposed to 4-NBB did not develop any tumors. Cancer studies on rats also revealed that exposure to 4-NBB led to increased incidence and multiplicity of bladder tumors. These findings provide strong evidence for the genotoxic effects of this compound.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 188.23 g/mol
• Formule: C₈H₁₆N₂O₃
• Degré de pureté: Min. 95%