5-Carboxyhydroxymethyluridine

CAS : 934743-11-0

Ref. 3D-NC159485

Informations sur le produit

• Nom: 5-Carboxyhydroxymethyluridine
• Synonymes: 1,2,3,4-Tetrahydro-α-hydroxy-2,4-dioxo-1-β-D-ribofuranosyl-5-pyrimidineacetic acid

Description

5-Carboxyhydroxymethyluridine is a hydroxylated nucleoside that is used to study DNA repair. It is a nucleotide analogue that has been modified at the hydroxyl group by methylation. 5-Carboxyhydroxymethyluridine can be converted back to uridine by escherichia coli hydroxylases, but this conversion does not occur in vivo. 5-Carboxyhydroxymethyluridine can be used as a substrate for methyltransferase enzymes, which are involved in DNA repair. The enzyme 5'-methylthioadenosine phosphorylase converts 5-carboxyhydroxymethyluridine into S-adenosylhomocysteine and adenine. This conversion can be reversed by the enzyme methionine synthase. Some homologues of 5-carboxyhydroxymethyluridine have been found in nature and other modifications have been made on the

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 318.24 g/mol
• Formule: C₁₁H₁₄N₂O₉
• Degré de pureté: Min. 95%
• Couleur/Forme: Powder