3-Deazauridine

CAS : 23205-42-7

Ref. 3D-ND16524

Informations sur le produit

• Nom: 3-Deazauridine
• Synonymes: 4-Hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridinone1-β-D-Ribofuranosyl-4-hydroxy-2-pyridone, 1-beta-D-ribofuranosylpyridine-2,4(1H,3H)-dione, 1-β-<span class="text-smallcaps">D</span>-Ribofuranosyl-4-hydroxy-2-pyridone, 2(1H)-Pyridinone, 4-hydroxy-1-beta-D-ribofuranosyl- (9CI), 2(1H)-Pyridinone, 4-hydroxy-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, 2(1H)-Pyridone, 4-hydroxy-1-beta-D-ribofuranosyl-, 2(1H)-Pyridone, 4-hydroxy-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, 2-hydroxy-1-(beta-D-ribofuranosyl)pyridin-4(1H)-one, 3-Deazuridine, 4-Hydroxy-1-(β-<span class="text-smallcaps">D</span>-ribofuranosyl)-2-pyridone, 4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone, 4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridone, 4-Hydroxy-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-2(1H)-pyridinone, 4-hydroxy-1-(beta-D-ribofuranosyl)pyridin-2(1H)-one, Nsc 126849

Description

3-Deazauridine is a uridine analog that inhibits the synthesis of DNA, RNA, and protein. It has been shown to inhibit the activity of 3-deazauridine synthetase in HL-60 cells. 3-Deazauridine also has significant cytotoxicity against colorectal adenocarcinoma cells and synergistic effects when used with other chemotherapeutic agents. The mechanism of action of 3-deazauridine is similar to that of other enzyme inhibitors, such as glycosidic bond formation or competitive inhibition. The sample preparation for this drug is complicated by its insolubility in water.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 243.21 g/mol
• Formule: C₁₀H₁₃NO₆
• Degré de pureté: Min. 97 Area-%
• Couleur/Forme: White Powder