2',3'-Dideoxyadenosine-5'-monophosphate

CAS : 26315-32-2

Ref. 3D-ND30902

Informations sur le produit

• Nom: 2',3'-Dideoxyadenosine-5'-monophosphate
• Synonymes: [(2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydro-2-furanyl]methyl dihydrogen phosphate2',3'-Dideoxy-5'-adenylic acid, [(2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl]methyl phosphate, 2-furanmethanol, 5-(6-amino-9H-purin-9-yl)tetrahydro-, dihydrogen phosphate (ester), ion(2-), (2S,5R)-

Description

2',3'-Dideoxyadenosine-5'-monophosphate (ddAMP) is an adenosine analog that is a substrate for the enzyme dideoxyribonucleoside kinase. It is activated by phosphorylation to the 5' ends of DNA molecules and inhibits viral replication. ddAMP has been shown to be effective in treating human immunodeficiency virus (HIV) infection, at least in part, by inhibiting the production of p24 antigen levels and reducing the number of CD4+ lymphocytes. The mechanism of action may involve binding to HIV-1 RNA, which prevents it from interacting with cellular dsDNA and inhibits its transcription into DNA.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 315.22 g/mol
• Formule: C₁₀H₁₄N₅O₅P
• Degré de pureté: Min. 95%