5-Methyl-2-thiouridine

CAS : 32738-09-3

Ref. 3D-NM08039

Informations sur le produit

• Nom: 5-Methyl-2-thiouridine
• Synonymes: 5-Methyl-2-thio-D-uridinem5s2U, 1-β-<span class="text-smallcaps">D</span>-Ribofuranosyl-2-thiothymine, 2-Thio-5-methyluridine, 2-Thioribosylthymine, 2-Thioribothymidine, 2-Thioribothymine, 5-methyl-1-beta-D-ribofuranosyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one, 5-methyl-1-pentofuranosyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one, Methyl thiouridine, Uridine, 5-methyl-2-thio-, 1-β-D-Ribofuranosyl-2-thiothymine, 5-Methyl-2-thiouridine

Description

5-Methyl-2-thiouridine is a nucleotide that is found in the type strain of Escherichia coli. It has been shown to be an effective inhibitor of protein synthesis, with optimum concentration at 0.1 mM. 5-Methyl-2-thiouridine binds to the ribosome and inhibits its activity. 5-Methyl-2-thiouridine also interacts with human mitochondrial RNA and alters its structure, leading to an antibody response that protects against infection by the bacteria in question. This nucleotide has also been shown to inhibit bacterial growth in wastewater treatment plants. The chemical structures of 5-methyluridine are similar to those of uridine except for a methyl group on the second carbon atom (5 position). The presence of this methyl group confers increased water permeability and decreased kinetic energy on the molecule, which can be detected using nuclear magnetic resonance spectroscopy.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 274.29 g/mol
• Formule: C₁₀H₁₄N₂O₅S
• Degré de pureté: Min. 95%
• Couleur/Forme: White Powder