GD1b-Ganglioside ammonium

CAS : 19553-76-5

Ref. 3D-OG175968

Informations sur le produit

• Nom: GD1b-Ganglioside ammonium
• Synonymes: (2R,4S,5R,6R)-2-[(2R,3S,4S,5R,6S)-5-[(2R,3S,4S,5S,6S)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(E)-2-hydroxy-1-[(octadecanoylamino)methyl]heptadec-3-enoxy]tetrahydropyran-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl]oxy-5-amino-6-[3-[(2R,4R,5S,6S)-5-amino-2-carboxy-4-hydroxy-6-(1,2,3-trihydroxypropyl)tetrahydropyran-2-yl]oxy-1,2-dihydroxy-propyl]-4-hydroxy-tetrahydropyran-2-carboxylic acid, G_D1b, GD1b ganglioside, Ganglioside C₁, Ganglioside G₂, Ganglioside G₂ (hexasaccharide), Ganglioside G_D1b, Ganglioside G_III, Ganglioside GD1b, Disialo, Diammonium Salt, Bovine Brain

Description

GD1b ganglioside (shown as ammonium salt) is one of the major gangliosides in neuronal and glial membranes. It has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with its two sialic acids linked α2,3/α2,8 to the inner galactose residue, and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GD1b ganglioside acts as a receptor for BK virus, as well as for heat-labile LTII-a toxin, produced by enteropathogenic E. coli. GD1b ganglioside also interacts with tetanus neurotoxin (TeNT) and is crucial for its entry into cells (Kolter, 2012). The functional significance of ammonia in the brain is not yet fully understood: see (Modi 1994).

• Marque: Biosynth

Propriétés chimiques

• Degré de pureté: Min. 95%