Informations sur le produit
CGP 12177 hydrochloride is a catecholamine that acts as an agonist at the alpha-1 adrenergic receptor. It has been used to study the pharmacological properties of this receptor and its sensitivity to various drugs. CGP 12177 hydrochloride has shown some antagonist activity against isoprenaline and other catecholamines, but it is not selective for alpha-1 receptors. The imidazolone ring in this agent appears to be important for binding to the receptor, which may be due to its structural similarity to adrenaline. CGP 12177 hydrochloride binds to the agonist binding site on the alpha-1 adrenergic receptor, activating Gs proteins and stimulating adenylyl cyclase. This increases intracellular levels of cyclic AMP (cAMP) and activates protein kinase A (PKA), which phosphorylates proteins such as glycogen synthase kinase 3 (GSK3) and protein kinase C
Propriétés chimiques
Question d’ordre technique sur : 3D-PCA20832 CGP 12177 hydrochloride
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