9-(3-Hydroxypropoxy)guanine

CAS : 114778-60-8

Ref. 3D-PEA77860

Informations sur le produit

• Nom: 9-(3-Hydroxypropoxy)guanine
• Synonymes: Brl 44385, 2-Amino-1,9-dihydro-9-(3-hydroxypropoxy)-6H-purin-6-one, 6H-Purin-6-one, 2-amino-1,9-dihydro-9-(3-hydroxypropoxy)-, 2-amino-9-(3-hydroxypropoxy)-3,9-dihydro-6H-purin-6-one
• CAS: 114778-60-8

Description

9-(3-Hydroxypropoxy)guanine is an aldehyde oxidase inhibitor that blocks the production of formaldehyde, which is a reactive metabolite that can cause DNA damage. 9-(3-Hydroxypropoxy)guanine has been shown to inhibit the oxidation of purines in incubations with c1-6 alkyl. It also inhibits the oxidation of guanine and deoxyguanine mediated by aldehyde oxidase. This drug is a prodrug, which is converted to its active form in the cytosol by cytochrome p450 enzymes. The metabolic transformation of 9-(3-hydroxypropoxy)guanine into its active form occurs primarily in hepatocytes. 9-(3-Hydroxypropoxy)guanine has been shown to be effective against oxidative stress induced by homogenates and liver cells from humans, as well as cytosolic extracts from human hepatocytes.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 225.2 g/mol
• Formule: C₈H₁₁N₅O₃
• Degré de pureté: Min. 95%