Tetanus Toxin (830-844) peptide - QYIKANSKFIGITEL

Ref. 3D-PP51153

Informations sur le produit

• Nom: Tetanus Toxin (830-844) peptide - QYIKANSKFIGITEL
• Synonymes: H-QYIKANSKFIGITEL-OH

Description

TET 830/Tetanus Toxin (830-844) peptide - QYIKANSKFIGITEL

Tetanus

Tetanus is a life-threatening condition caused by Clostridium tetani bacteria. After entering the body through a break in the skin, they produce a toxin that causes convulsions and severe muscle spasms, that can be strong enough to fracture bones of the spin. Tetanus toxin inhibits neurotransmitter release by binding to peripheral neuronal synapses. The substance will then be internalized and transported to the spinal cord where it will be able to move between postsynaptic and presynaptic neurons.

For the time being, there is no cure for tetanus. Indeed, the extreme potency of the tetanospasmin toxin prevents immunity in infected people, leading to 30-40% deaths among this population. Symptoms usually start 4 to 21 days after infection, and most of the people get them after about 10 days.

Tetanus vaccine

Thanks to the widespread use of tetanus vaccines, infections are rare in many countries. However, this disease remains a threat for people without access to vaccination. Immunization against tetanus is recommended for all infants between 6 and 8, all children, and all adults.

Immunization is achieved by 3 or 4 injection of tetanus toxoid (inactivated toxin) completed by booster injections every 10 years.

Tetanus Toxoid

Tetanus toxoid is the altered form of tetanus toxin (UniProt: P04958), used in vaccines to prevent tetanus infection.

Tetanus Toxin QYIKANSKFIGITEL peptide explications SB-PEPTIDE

Tetanus toxin actes as a zinc endopeptidase, that cleaves the ’76-Gln-|-Phe-77′ bond within synaptobrevin-2, thereby impeding the release of neurotransmitters.

TET 830 - QYIKANSKFIGITEL peptide

Among the 1315 amino acids composing tetanus toxoid, researchers identified the fragment (830-844) QYIKANSKFIGITE, also known as « tetanus toxin P2 protein ». This fragment displays antigenic properties resembling the neurotoxin released by Clostridium tetani. Hence, it can function as an appropriate epitope for CD4+ T-cells, stimulating the release of IFN-γ, that promotes macrophage activity and coordinates lymphocyte-endothelium interactions.

Note that the modified version of TET 830 can also be purchased at SB-PEPTIDE following the link hereafter: TET 830 modified/T-helper epitope from tetanus toxoid - AQYIKANSKFIGITEL

• Marque: Biosynth