HDAC8-IN-1

CAS : 1417997-93-3

Ref. 3D-SGC99793

Informations sur le produit

• Nom: HDAC8-IN-1
• Synonymes: (2E)-N-Hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide
• Marque: Biosynth
• Description: HDAC8-IN-1 is a small molecule inhibitor of class I histone deacetylases (HDACs). It is a potent inhibitor of HDAC8, the most abundant HDAC in the human genome. In vitro studies have shown that HDAC8-IN-1 inhibits self-renewal and differentiation of cancer stem cells. In vivo, HDAC8-IN-1 treatment inhibited tumor growth in mouse models of leukemia and breast cancer. The pharmacological inhibition of HDAC8 with HDAC8-IN-1 has been shown to inhibit expression of genes involved in cell cycle regulation, angiogenesis, metastasis, and immune suppression.

Propriétés chimiques

• Masse moléculaire: 345.39 g/mol
• Formule: C₂₂H₁₉NO₃
• Degré de pureté: Min. 95%