Piclamilast

CAS : 144035-83-6

Ref. 3D-UFA03583

Informations sur le produit

• Nom: Piclamilast
• Synonymes: 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide, 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-p-anisamide, 3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide, Benzamide, 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-, Ccris 8304, Cpodpmb, N-(3,5-Dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide, Piclamilast [INN], Rp 73401, Rpr 73401

Description

Piclamilast is a low-potency, non-selective, reversible inhibitor of phosphodiesterase (PDE) enzymes. It has been shown to have therapeutic potential for inflammatory bowel disease and asthma. Piclamilast blocks the production of pro-inflammatory cytokines such as eosinophil cationic protein and basic proteins in response to lipopolysaccharide (LPS).
Piclamilast inhibits the inflammatory response induced by LPS by reducing the expression of pro-inflammatory cytokines, including IL-8, IL-1β, TNFα and IL-6.
Piclamilast also has inhibitory effects on protein kinases such as c-jun phosphorylation and polymerase chain reaction.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 381.25 g/mol
• Formule: C₁₈H₁₈Cl₂N₂O₃
• Degré de pureté: Min. 95%