Informations sur le produit
LY2857785 is a potent and selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). It inhibits the proliferation of cancer cells by interfering with cellular organelles, such as the mitochondria. LY2857785 has been shown to potently inhibit the proliferation of lymphocytic leukemia and fibrolamellar carcinoma cells. Inhibition of CDK4/6 activity leads to a decrease in transcriptional regulation, which may be due to an inhibition of cyclin D1 expression. The mechanism studies revealed that LY2857785 synergistically interacts with a number of inflammatory bowel disease drugs, including thalidomide and 5-aminosalicylic acid. This drug is effective against chronic lymphocytic leukemia at doses lower than those required for cancer treatment, making it a potential candidate for the prevention or treatment of this disease.
Propriétés chimiques
Question d’ordre technique sur : 3D-UPC90354 LY2857785
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