Benzo[b]furan-7-carboxaldehyde

CAS : 95333-14-5

Ref. 3D-VDA33314

Informations sur le produit

• Nom: Benzo[b]furan-7-carboxaldehyde
• Synonymes: 7-Benzofurancarboxaldehyde, 7-Formylbenzofuran

Description

Benzo[b]furan-7-carboxaldehyde (BBA) is a mitochondrial uncoupler that can be used as an alternative to the toxic and expensive compound dinitrophenol. BBA induces mitochondrial dysfunction and cytosolic Ca2+ levels by inhibiting ATP synthesis and mitochondrial membrane potential. This leads to oxidative injury, which can be reversed with pharmacological treatments. BBA has been shown to have in vitro antifungal activity against Candida albicans and Saccharomyces cerevisiae, but it has not been tested on other fungi. It also has cardioprotective effects in vivo. In rats, intravenous administration of BBA raised the concentration of creatine kinase, indicating myocardial damage. Magnetic resonance spectroscopy revealed the induction of electrophysiological changes in rat cardiomyocytes after treatment with BBA. These changes were accompanied by actin filament depolymerization and disruption of sarcomere structure. Molecular

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 146.14 g/mol
• Formule: C₉H₆O₂
• Degré de pureté: Min. 95%