Informations sur le produit
- 1-((2R,4R)-2-(1H-Benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea
- Glasdegib
- N-[(2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N′-(4-cyanophenyl)urea
- Urea, N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N′-(4-cyanophenyl)-
PF 04449913 is a potent inhibitor of the enzyme caspase-3. It has been shown to have long-term efficacy and good tolerability in phase II clinical trials. PF 04449913 interacts with cell factor, a protein that is involved in the regulation of cell growth, differentiation, and apoptosis. This inhibition leads to inhibition of myeloid leukemia cells, which are important for the production of white blood cells and platelets in the body. PF 04449913 also inhibits Toll-like receptor signaling pathways that are activated by microbial products such as lipopolysaccharide (LPS). In vivo models have shown PF 04449913 to be well tolerated at doses up to 150 mg/kg/day and to reduce tumor size in mouse xenografts.
Propriétés chimiques
Question d’ordre technique sur : 3D-VTB17327 PF 04449913
Si vous souhaitez demander un devis ou passer commande, veuillez plutôt ajouter les produits souhaités à votre panier, puis demander un devis ou passer commande à partir de votre panier. C'est une méthode plus rapide, plus économique, et vous pourrez bénéficier des remises disponibles ainsi que d'autres avantages
