Benzeneacetic acid, 4-(methoxycarbonyl)-2-propyn-1-yl-, methyl ester
CAS : 146464-90-6
Ref. 3D-WFA46490
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Informations sur le produit
Nom :
Benzeneacetic acid, 4-(methoxycarbonyl)-2-propyn-1-yl-, methyl ester
Synonymes :
- 4-(Methoxycarbonyl)-α-2-propyn-1-ylbenzeneacetic acid methyl ester
- 4-(Methoxycarbonyl)-Alpha-Propargylphenyl-Acetic Acid Methyl Ester
- Α-Propargylhomoterephthalic Acid Dimethyl Ester
Description :
Benzeneacetic acid, 4-(methoxycarbonyl)-2-propyn-1-yl-, methyl ester is a cytotoxic compound that has been shown to exhibit antitumor activity. It is a prodrug of pralatrexate, which can be hydrolyzed by esterases or glucuronidases to the active form. The active form exhibits cytotoxicity against tumours and is effective in killing cells with low levels of glutathione. Pralatrexate has been shown to have an inhibitory effect on the growth of leukemic cells.
Benzeneacetic acid, 4-(methoxycarbonyl)-2-propyn-1-yl-, methyl ester is a secondary metabolite produced by Streptomyces sp. It inhibits the enzyme dihydrofolate reductase and affects DNA synthesis and repair by inhibiting thymidylate synthase and dTMP kinase activities
Avis:
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Marque:
Biosynth
Stockage à long terme :
Notes :
Propriétés chimiques
Masse moléculaire :
246.26 g/mol
Formule :
C14H14O4
Degré de pureté :
Min. 95%
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