Merbarone

CAS : 97534-21-9

Ref. 3D-XDA53421

Informations sur le produit

• Nom: Merbarone
• Synonymes: 4,6-dioxo-N-phenyl-2-thioxohexahydropyrimidine-5-carboxamide, 5-(N-Phenylcarboxamido)-2-thiobarbituric acid, 5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-N-phenyl-2-thioxo-, 6-hydroxy-4-oxo-N-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, Ccris 8215, Hexahydro-4,6-dioxo-N-phenyl-2-thioxo-5-pyrimidinecarboxamide, Nsc 336628

Description

Merbarone is a cytotoxic agent that inhibits the growth of cancer cells by binding to the nuclear DNA. It has been shown to bind to topoisomerase II and inhibit DNA synthesis in vitro. Merbarone also has potent antitumor activity in vivo and induces apoptosis in squamous carcinoma cells. This drug also interferes with the oxidative injury pathway, which may be due to its ability to induce apoptosis in malignant brain cells. Merbarone has been shown to have genotoxic effects on k562 cells, which may be due to its ability to inhibit topoisomerase I and II enzymes.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 263.27 g/mol
• Formule: C₁₁H₉N₃O₃S
• Degré de pureté: Min. 95%