86-MM1286.03-0025 - terconazole-n-oxide

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Terconazole

Terconazole, a triazole antifungal, disrupts fungal cell walls by inhibiting ergosterol synthesis, active against Candida.

<p>Terconazole is an azole antifungal agent with action on fungal cell membranes by inhibiting ergosterol biosynthesis and is used for treating vaginal yeast infections.</p>

<p>Applications Terconazole belongs to a new chemical class of antifungal agents, the triazoles. Terconazole has a far greater selectively for yeast cytochrome P-450 than for mammalian microsomal cytochrome P-450 and is used as topical treatment of mycotic vaginitis. Terconazole may also be used in vitro as a potent antifungal agent to prevent the morphogenetic transformation of yeast into (pseudo-)mycelium form of Candida albicans.<br>References Cauwenbergh, G., Vanden Bossch H.: J. Reprod. Med., 34, 588 (1989); Del Palacio-Hernanz, A., et. al.: Chemioterapia, 3, 192 (1984); Van Cutsem, J., et. al.: Chemotherapy, 29, 322 (1983);<br></p>

TERCONAZOLE CRS