AC-40818 - 712-dimethylbenzaanthracene-98 | 57-97-6

NVP-BHG712 isomer shows conserved non-bonded binding to EPHA2 and EPHB4.

NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and

<p>Applications Butaperazine Dihydrochloride, is a derivative of Perazine (P285800). It has antipsychotic potencies used as antipsychotic drug.<br>References Rijcken, C., et al.: J. Clinic. Psychopharmacol., 23 (6), 657 (2003);<br></p>

<p>Applications Benzophenone estrogenicity toxicity structure activity.<br>References Gantichev, T., et al.: J. Med. Chem., 37, 4164 (1994), Routledge, E., et al.: Biol. Chem., 272, 3280 (1997), Routledge, E., et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998),<br></p>

<p>Applications NVP-BHG712 can be used in biological study and therapeutic use of combinations of kinase inhibitors for treating colorectal cancer.<br>References Stassi, G., et al.: PCT Int. Appl., WO 2016193955 A1 20161208 (2016)<br></p>

<p>Applications Acetophenone is a reagent used in the production of fragrances and resin polymers.This compound is a contaminant of emerging concern (CECs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Perez, D., et al.; Bioorg. Med. Chem., 17, 6914 (2009), Giet, J., et al.: J. Agric. Food Chem., 57, 6787 (2009), Dimoula, K., et al.: Biotechnol. J., 4, 712 (2009),<br></p>

<p>Applications BW B70C is a 5-LO (5-lipoxygenase) inhibitor.<br>References Averina, E.B., et al.: Bioorg. Med. Chem, 24, 712 (2016)<br></p>

<p>Applications 1-[(2-Chlorophenyl)phenylmethyl]piperazine is a novel compound derived from the previously reported N-type calcium channel blocker NP118809 (1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one).<br>References Maggi, C., et al.: Neuroscience, 34, 243 (1990), Evans, A., et al.: Brain Res., 712, 265 (1996), Kerr, L., et al.: Eur. J. Pharmacol., 146, 181 (1998), Hu, L., et al.: Bioorg. Med. Chem. Lett., 9, 907 (1999),<br></p>

<p>Applications Des[2’-(1H-tetrazol-5-yl)] 2-Cyanolosartan is a derivative of Losartan Potassium (L470500), a an angiotensin II antagonist and is commonly used to significantly reduce risk of new onset atrial fibrillation and associated stroke in high-risk patients.<br>References Madasu, S., et al.: Org. Process Res. Dev., 16, 2025 (2012); Pitt, B., et al.: The Lancet, 355, 1582 (2000); Wachtell, K., et al.: J. Am. Coll. Cardiol., 45, 712 (2005)<br></p>

<p>Applications Methyl 3-(4-Cyano-4-(N-phenylpropionamido)piperidin-1-yl)propanoate is an impurity compound of Remifentanil(R143500). Remifentanil is a labelled synthetic mu-opioid agonist, a controlled compound (opiate).<br>References James, M.K., et al.: J. Pharmacol. Exp. Ther., 259, 712 (1991), Hoffman, W.E., et al.: Anesthesiology, 79, 107 (1993), Selinger, K., et al.: J. Pharm. Biomed. Anal., 12, 243 (1994), Richardson, T.D., et al.: Expert Opin. Drug Saf., 4, 643 (2005),<br></p>

<p>Applications Antimycotic allylamine. An antifungal (topical) agent.<br>References Georgopoulos, A., et al.: Antimicrob. Ag. Chemother., 19, 386 (1981), Meingassner, J.C., et al.: J. Invest. Dermatol., 77, 444 (1981), Paltauf, F., et al.: Biochim Biophys. Acta, 712, 268 (1982), Aggarwal, D., et al.: J. Pharm. Pharmacol., 56, 1509 (2004),<br></p>

<p>Applications (Z)-Naftifine is the Z-isomer of Naftifine (N213100); an antimycotic allylamine and antifungal (topical) agent.<br>References Georgopoulos, A., et al.: Antimicrob. Ag. Chemother., 19, 386 (1981); Meingassner, J.C., et al.: J. Invest. Dermatol., 77, 444 (1981); Paltauf, F., et al.: Biochim Biophys. Acta, 712, 268 (1982); Aggarwal, D., et al.: J. Pharm. Pharmacol., 56, 1509 (2004)<br></p>

<p>Applications Remifentanil derivative.<br>References James, M.K., et al.: J. Pharmacol. Exp. Ther., 259, 712 (1991), Hoffman, W.E., et al.: Anesthesiology, 79, 107 (1993), Selinger, K., et al.: J. Pharm. Biomed. Anal., 12, 243 (1994), Richardson, T.D., et al.: Expert Opin. Drug Saf., 4, 643 (2005),<br></p>

<p>Applications Labelled synthetic mu-opioid agonist. This is a controlled substance (opiate).<br>References James, M.K., et al.: J. Pharmacol. Exp. Ther., 259, 712 (1991), Hoffman, W.E., et al.: Anesthesiology, 79, 107 (1993), Selinger, K., et al.: J. Pharm. Biomed. Anal., 12, 243 (1994), Richardson, T.D., et al.: Expert Opin. Drug Saf., 4, 643 (2005),<br></p>