Crk II (phospho Tyr221) rabbit pAb

Ref. EK-ES1448

Informations sur le produit

• Nom: Crk II (phospho Tyr221) rabbit pAb
• Synonymes: CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38

Description

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008],

• Marque: ELK Biotechnology