LRP6 (Phospho Thr1479) rabbit pAb

Ref. EK-ES20181

Informations sur le produit

• Nom: LRP6 (Phospho Thr1479) rabbit pAb
• Synonymes: Low-density lipoprotein receptor-related protein 6 (LRP-6)

Description

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009],

• Marque: ELK Biotechnology