VHR rabbit pAb

Ref. EK-ES3958

Informations sur le produit

• Nom: VHR rabbit pAb
• Synonymes: DUSP3; VHR; Dual specificity protein phosphatase 3; Dual specificity protein phosphatase VHR; Vaccinia H1-related phosphatase; VHR

Description

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast ca

• Marque: ELK Biotechnology